Do I need to save my game manually?

In Grand Theft Auto V on PS3 or Xbox, do I ever need to save my game manually (by sleeping in a bed or using my cell phone) or can I rely completely on the auto save feature?

A related detail, inspired by Nolonar's answer below is: If I do save my game manually, using quicksave or sleeping in a bed) should I save it in the same slot as the autosave, or a different slot? Is there any way to prevent the "Are you sure you want to overwrite?!" message that comes up at the start of each play session?

(In both cases, assuming I never want to "rewind time", i.e. I only ever want to load my latest save.)

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2022-07-25 20:44:03
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